Treinamento físico materno atenua efeitos da desnutrição perinatal

Este artigo foi aceito para publicação no British Journal of Nutrition, 2012.
Parabéns ao grupo de pesquisa NNI-DOHaD e ao Núcleo de Educação Física e Ciências do Esporte do CAV - UFPE

Programmed changes in the adult rat offspring caused by maternal protein-restriction during gestation and lactation are attenuated by maternal moderate-low physical training


Marco Fidalgo1; Filippe Falcão-Tebas2; Adriano Bento-Santos2; Elaine de Oliveira3; José Firmino Nogueira-Neto3; Egberto Gaspar de Moura3; Patrícia Cristina Lisboa3; Raul Manhães de Castro2; Carol Góis Leandro1

Affiliations of authors:
1 Department of Physical Education and Sports Science, CAV, Federal University of Pernambuco, Brazil.
2 Department of Nutrition, Federal University of Pernambuco, Brazil.
3 Department of Physiological Sciences, Roberto Alcantara Gomes Biology Institute, State University of Rio de Janeiro, Brazil

Abstract
The effects of maternal moderate-low physical training on post-natal development, glucose homeostasis, and leptin concentration in adult offspring submitted to a low-protein diet during the perinatal period were investigated. Male Wistar rats (aged 150 d old) were divided into four groups according to their mother´s group: untrained (NTp, n = 8); trained (Tp, n = 8); untrained with a low-protein diet (NT+LPp, n = 8); and trained with a low-protein diet (T+LPp, n = 8). Trained mothers were submitted to a protocol of moderate physical training over a period of 4 weeks (treadmill, 5 days/wk, 60 min/day, at 65% VO2max) before mating. At pregnancy, the intensity and duration of the exercise was progressively reduced (50-20 min/day, at 65-30% VO2max). The low-protein diet groups received an 8% casein diet, and their peers received a 17% casein diet during gestation and lactation. The pup’s birth weight and somatic growth were recorded weekly up to the 150th day. Fasting blood glucose, cholesterol, serum leptin concentration, glucose and insulin tolerance tests were evaluated. The Tp animals showed no changes in the somatic and biochemical parameters, while the NT+LPp group showed a greater abdominal circumference, hyperglycaemia, hypercholesterolemia, glucose intolerance, and lower plasma leptin. In the T+LPp animals, all of those alterations were reversed except for the plasma leptin concentration. In conclusion, the effects of a perinatal low-protein diet on the growth and development, glucose homeostasis and serum leptin concentration in the offspring were attenuated in pups from trained mothers.


Key-words: Glucose homeostasis; gestational exercise; developmental plasticity, perinatal undernutrition