Dia do Professor de Educação Física-01/09

Prezados amigos e colegas,

Sendo esse blog associado ao curso de Educação Física do CAV-UFPE, não poderíamos esquecer da data de hoje. Muitos profissionais da área não a reconhecem por varias razões, mas independente disso usemos a data de hoje para pensarmos na importância da profissão do Professor de Educação Física. Uma profissão que busca o desenvolvimento de habilidades motoras e cognitivas além da melhoria na qualidade de vida do indivíduo, que tem muitas belezas mas que é muitas vezes menosprezada pela sociedade.

Um bom dia do Professor de Educação Física a todos os nossos alunos e colegas!

Front. Hum. Neurosci. 6:249. doi: 10.3389/fnhum.2012.00249

Differential vulnerability of substantia nigra and corpus striatum to oxidative insult induced by reduced dietary levels of essential fatty acids

Henriqueta D. Cardoso, Priscila P. Passos, Claudia J. Lagranha, Anete C. Ferraz, Eraldo F. Santos Júnior, Rafael S. Oliveira, Pablo E. L. Oliveira, Rita de C. F. Santos, David F. Santana, Juliana M. C. Borba, Ana P. Rocha-de-Melo,Rubem C. A. Guedes, Daniela M. A. F. Navarro, Geanne K. N. Santos, Roseane Borner, Cristovam W. Picanço-Diniz,Eduardo I. Beltrão, Janilson F. Silva, Marcelo C. A. Rodrigues, Belmira L. S. Andrade da Costa.

• Oxidative stress (OS) has been implicated in the etiology of certain neurodegenerative disorders. Some of these disorders have been associated with unbalanced levels of essential fatty acids (EFA). The response of certain brain regions to OS, however, is not uniform and a selective vulnerability or resilience can occur. In our previous study on rat brains, we observed that a two-generation EFA dietary restriction reduced the number and size of dopaminergic neurons in the substantia nigra (SN) rostro-dorso-medial. To understand whether OS contributes to this effect, we assessed the status of lipid peroxidation (LP) and anti-oxidant markers in both SN and corpus striatum (CS) of rats submitted to this dietary treatment for one (F1) or two (F2) generations. Wistar rats were raised from conception on control or experimental diets containing adequate or reduced levels of linoleic and α-linolenic fatty acids, respectively. LP was measured using the thiobarbituric acid reaction method (TBARS) and the total superoxide dismutase (t-SOD) and catalase (CAT) enzymatic activities were assessed. The experimental diet significantly reduced the docosahexaenoic acid (DHA) levels of SN phospholipids in the F1 (~28%) and F2 (~50%) groups. In F1 adult animals of the experimental group there was no LP in both SN and CS. Consistently, there was a significant increase in the t-SOD activity (p < 0.01) in both regions. In EF2 young animals, degeneration in dopaminergic and non-dopaminergic neurons and a significant increase in LP (p < 0.01) and decrease in the CAT activity (p < 0.001) were detected in the SN, while no inter-group difference was found for these parameters in the CS. Conversely, a significant increase in t-SOD activity (p < 0.05) was detected in the CS of the experimental group compared to the control. The results show that unbalanced EFA dietary levels reduce the redox balance in the SN and reveal mechanisms of resilience in the CS under this stressful condition.

Finalizada as Inscrições para o I SIMM

Prezados Amigos,

Graças a grande procura para participar do nosso I Simpósio Internacional de Mitocondria e Metabolismo, finalizamos as inscrições devido ao numero de vagas. Obrigada pela atenção e compreensão.

Atenciosamente,

Comissão Organizadora I SIMM

J Biomed Biotechnol. 2012;2012:805418. Epub 2012 Aug 13.

Maternal Moderate Physical Training during Pregnancy Attenuates the Effects of a Low-Protein Diet on the Impaired Secretion of Insulin in Rats: Potential Role for Compensation of Insulin Resistance and Preventing Gestational Diabetes Mellitus.

Leandro CG, Fidalgo M, Bento-Santos A, Falcão-Tebas F, Vasconcelos D, Manhães-de-Castro R, Carpinelli AR, Hirabara SM, Curi R.

Source

Department of Nutrition, Federal University of Pernambuco, 50670-901 Recife, PE, Brazil.

Abstract

The effects of pregestational and gestational low-to-moderate physical training on insulin secretion in undernourished mothers were evaluated. Virgin female Wistar rats were divided into four groups as follows: control (C, n = 5); trained (T, n = 5); low-protein diet (LP, n = 5); trained with a low-protein diet (T + LP, n = 5). Trained rats ran on a treadmill over a period of 4 weeks before mate (5 days week(-1) and 60 min day(-1), at 65% of VO(2max)). At pregnancy, the intensity and duration of the exercise were reduced. Low-protein groups were provided with an 8% casein diet, and controls were provided with a 17% casein diet. At third day after delivery, mothers and pups were killed and islets were isolated by collagenase digestion of pancreas and incubated for a further 1 h with medium containing 5.6 or 16.7 mM glucose. T mothers showed increased insulin secretion by isolated islets incubated with 16.7 mM glucose, whereas LP group showed reduced secretion of insulin by isolated islets when compared with both C and LP + T groups. Physical training before and during pregnancy attenuated the effects of a low-protein diet on the secretion of insulin, suggesting a potential role for compensation of insulin resistance and preventing gestational diabetes mellitus.http://www.ncbi.nlm.nih.gov/pubmed/22927722